One drop is all it takes to turn a lady into a slut.

After a string of rejections leaves him depressed, Tomoyuki takes a mysterious "popularity medicine" he bought from a suspicious woman. When he wakes up the next morning, he has been transformed into a beautiful girl named Syuri. Despite the change, his anatomy is larger than ever, and he soon discovers his semen contains potent aphrodisiac ingredients. Now, every woman he encounters is driven into a primal, uncontrollable frenzy by his highly concentrated "horny" essence.